Frenemies within: An Endocarditis Case in Behcet's Disease
JOURNAL OF PERSONALIZED MEDICINE(2021)
摘要
A 57-year female patient diagnosed with Behcet's disease, on azathioprine, was noticed to have at a routine examination antinuclear and antiphospholipid antibodies. An overlapping lupus-like syndrome was diagnosed; hydroxychloroquine and aspirin were added. Three years later, the patient presented with dyspnea and sweating, with no fever. A cardiac bruit was noted; a giant vegetation was detected by echocardiography. Laboratory revealed severe thrombocytopenia, antiphospholipid antibodies and low complement. Blood cultures were positive for Abiotrophia defectiva serology and also revealed a chronic Coxiella burnetii infection. Antibiotic therapy, low-dose anticoagulation and control of the underlying disease mildly improved the platelet count, which fully recovered only after cardiac valve replacement. However, the Behcet's disease, initially quiescent, flared after the therapy of infections. We discuss potential links between Behcet's disease and the occurrence of antinuclear and antiphospholipid antibodies and Coxiella endocarditis in this setting. We also highlight the differences between the endocarditis in Behcet's disease, antiphospholipid syndrome, Coxiella burnetii and Abiotrophia defectiva infection, respectively. Intracellular infections may modify the presentation of autoimmune diseases. Confounding clinical features of Coxiella persistent infection and non-bacterial thrombotic endocarditis in Behcet's disease warrant further insight.
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关键词
thrombotic endocarditis,Behcet's disease,Coxiella burneti,Abiotrophia defectiva,thrombocytopenia,valve replacement,immune tolerance
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