A new mutation in mgrb mediating polymyxin resistance in Klebsiella variicola

Michael H Lenzi,Willames M B S Martins,Mélanie Roch,Patrícia L Ramos,Kirsty Sands,Rodrigo Cayô,Timothy R Walsh,Diego O Andrey,Ana C Gales

International Journal of Antimicrobial Agents（2021）

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摘要

•Three polymyxin-resistant Klebsiella variicola isolates were recovered from migratory birds•Polymyxin resistance was mediated by chromosomal mechanisms•A new mgrB variant was described and correlated with polymyxin resistance•This is the first report of an inactive MgrB leading polymyxin resistance in Klebsiella variicola

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关键词

Enterobacterales,Two-component systems,Migratory birds,Antimicrobial resistance

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