Protein kinase C theta (Prkcq) affects nerve degeneration and regeneration through the c-fos and c-jun pathways in injured rat sciatic nerves

Yi Wang,Nannan Gao,Yumei Feng,Min Cai,Yuting Li,Xi Xu,Huanhuan Zhang,Dengbing Yao

Experimental Neurology（2021）

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摘要

•Prkcq expression decreased significantly during sciatic nerve repair.•Prkcq may accelerate the early WD of SCs by a proapoptotic mechanism.•Prkcq affect the migration, proliferation, and apoptosis of SCs through c-fos and p-c-jun/c-jun pathways.

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关键词

Wallerian degeneration (WD),Rat,Sciatic nerve injury,Prkcq,Schwann cells,Nerve regeneration

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