Activity of Lymphostatin, A Lymphocyte Inhibitory Virulence Factor of Pathogenic Escherichia coli, is Dependent on a Cysteine Protease Motif

Andrew G Bease,Elizabeth A Blackburn,Cosmin Chintoan-Uta, Shaun Webb,Robin L Cassady-Cain,Mark P Stevens

Journal of Molecular Biology（2021）

引用 1|浏览3

暂无评分

摘要

•LifA shares a cysteine protease motif with bacterial toxins and secreted effectors.•C1480A substituted LifA has reduced inhibitory activity against T cells.•LifA is cleaved in T cells and this requires C1480 and endosome acidification.

查看译文

关键词

LifA,protein toxin,endosome acidification,endopeptidase,protein processing

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要