Tissue specificity of DNA repair: the CRISPR compass

Joana Ferreira da Silva,Mathilde Meyenberg,Joanna I. Loizou

TRENDS IN GENETICS（2021）

Cited 9|Views6

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Abstract

CRISPR-Cas9-mediated genome editing holds great promise for the correction of pathogenic variants in humans. However, its therapeutic implementation is hampered due to unwanted editing outcomes. A better understanding of cell type- and tissue-specific DNA repair processes will ultimately enable precise control of editing outcomes for safer and effective therapies.

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