Expression of Fc epsilon RI alpha and tryptase in human lung tissue during drug-induced anaphylactic death

The diagnosis of drug-induced anaphylactic death is an important component of forensic medicine. The purpose of this study was to explore the expression of Fc epsilon RI alpha and tryptase in human lung tissue during drug-induced anaphylactic death and its value for forensic medicine. The expression of Fc epsilon RI alpha and tryptase in lung tissues of the drug-induced anaphylactic death group (n = 30) and control group (who died due to sudden cardiac death, falling from a height, or traffic accidents, n = 30) was detected by immunohistochemistry and immunofluorescence staining. The difference in Fc epsilon RI alpha and tryptase expression in the lung tissue between the drug-induced anaphylactic death group and the control group was statistically significant (p < 0.05). The levels of Fc epsilon RI alpha and tryptase expression greatly increased in the lung tissue of the drug-induced anaphylactic death group, which may provide morphological evidence and a reference for the diagnosis of drug-induced anaphylactic death in forensic medicine.