Preparative Production Of An Enantiomeric Pair By Engineered Polyketide Synthases
CHEMICAL COMMUNICATIONS(2021)
Abstract
Using the updated module boundary of polyketide assembly lines, modules from the pikromycin synthase were recombined into engineered synthases that furnish an enantiomeric pair of 2-stereocenter triketide lactones at >99% ee with yields up to 0.39 g per liter of E. coli K207-3 in shake flasks.
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Key words
enantiomeric pair,preparative production
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