Construction Of 2-Alkynyl Aza-Spiro[4,5]Indole Scaffolds Via Sequential C-H Activations For Modular Click Chemistry Libraries
CHEMICAL COMMUNICATIONS(2021)
Abstract
Herein, we have developed a strategy of sequential C-H activations of indole to construct novel 2-alkynyl aza-spiro[4,5]indole scaffolds, which incorporated both alkyne and spiro-units into indole. Gram-scale synthesis and a one-pot, three-step synthesis demonstrated the utility of this protocol. Hybrid conjugates with an oseltamivir derivative further offered a powerful tool for the construction of a versatile spiroindole-containing library via click chemistry.
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Key words
C–H Activation
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