Proposal and clinical application of molecular genetic risk scoring system, “MRplus”, for BCR-ABL1 negative pediatric B-cell acute lymphoblastic leukemia- report from a single centre

Sanjeev Kumar Gupta,Sameer Bakhshi,Vineet Kumar Kamal,Ritu Gupta,Preity Sharma,Deepam Pushpam,Ranjit Kumar Sahoo,Atul Sharma

Leukemia Research（2021）

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摘要

•‘MRplus’ risk-score is being proposed for the risk-stratification in childhood B-ALL.•The integrated molecular genetic risk-score ‘MRplus’ can identify distinct subgroups in B-ALL.•‘MRplus’ score can risk-stratify B-ALL patients at baseline into those with good, intermediate and poor outcomes.

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关键词

Leukemia Genetics,Gene deletions in B-ALL,IKZF1plus,Childhood leukemia,Molecular genetics,MRplus Score

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