Myopathic Cardiac Genotypes Increase Risk for Myocarditis

•AM is an important cause of cardiac dysfunction following some viral infections and has been previously linked with genetic host susceptibilities.•Sequencing data for genes related to cardiomyocyte structure and function was compared between patients with AM and sex- and ancestry-matched heart-healthy control subjects.•Putatively DVs among these genes were found in ∼16% of AM cases, contributing to viral susceptibility.•Implicated genes are ones classically associated with cardiomyopathy or neuromuscular disorders with cardiac involvement, suggesting shared mechanistic pathways.•Phenotypes, including outcomes, were similar in subjects who have AM with and without DV, therefore genetic testing will be necessary to uncover this subtype and inform risk in relatives.