Eff ect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD 4 cell counts of more than 500 cells per μL : secondary outcome results from a randomised controlled trial

Research Department of Infection and Population Health (J O’Connor MSc, Prof A N Phillips PhD), and Institute for Global Health (Prof I Abubakar PhD), University College London, London, UK; Veterans Affairs Medical Center, Washington, DC, USA (M J Vjecha MD, Prof F Gordin MD); The George Washington University, Washington, DC, USA (Prof F Gordin); Oxford Centre for Clinical Tropical Medicine, Nuffield Department of Medicine, Oxford University, Oxford, UK (Prof B Angus MD); The Kirby Institute, University of New South Wales, Sydney, NSW, Australia (Prof D Cooper MD); STD and AIDS Clinical Research Laboratory, Evandro Chagas Clinical Research Institute (IPEC), Rio de Janeiro, Brazil (B Grinsztejn MD); Fundación Centro de Estudios Infectológicos, Buenos Aires, Argentina (G Lopardo MD); HIV and GU Medicine, Coventry and Warwickshire Partnership Trust, University of Warwick, Coventry, UK (Prof S Das MD); Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa (Prof R Wood DSc); Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, NC, USA (A Wilkin MD); University of Würzburg Medical Center, Department of Internal Medicine II, Würzburg, Germany (H Klinker MD); Chaingrai Prachanukroh Eff ect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial