Synthesis of water-soluble, ultrabright Cu nanoclusters with core-shell structure via facile reduction approach for determination of 4-nitrophenol

In this work, we reported a facile reduction approach for fabrication of water-soluble and ultrabright Cu nanoclusters with core-shell structure. A certain amount of reducing agent as NaBH4 was introduced into the polyethyleneimine-stabilized Cu nanoclusters (CuNCs@PEI) system, which exhibited 4-fold fluorescence enhancement along with a blue shift of the emission peak. The variations of morphology, valence states and functional groups demonstrated that a Cu shell was formed surround CuNCs (defined as CuNCs-Cu@PEI), attributable to metal complex (PEI-Cu+ and PEI-Cu2+) reduction. The effect of core-shell morphology on luminous and electron relaxation mechanism of CuNCs-Cu@PEI was investigated via temperature-dependent steady and time-resolved fluorescence measurements. The CuNCs-Cu@PEI with a high fluorescence quantum yields of 22.59% were able to homogeneously disperse in aqueous phase, indicating their potential applications in biological labeling, sensing and in vivo imaging. Finally, the CuNCs-Cu@PEI was employed as a fluorescence probe to determine 4-nitrophenol, of which the detection limit was much lower than initial CuNCs@PEI.