Characterization and allogeneic transplantation of a novel transgenic cone-rich donor mouse line

Ying V Liu,Derek Teng,Gregory J Konar,Dzhalal Agakishiev,Alexis Biggs-Garcia,Sarah Harris-Bookman,Minda M McNally,Catalina Garzon,Saalini Sastry,Mandeep S Singh

Experimental Eye Research（2021）

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摘要

•The OPN1LW-EGFP/NRL−/− mouse has a cone-rich retina expressing a cone-specific EGFP reporter.•OPN1LW.EGFP reporter expression increased transient retinal degeneration that is typically seen in NRL−/− mice.•Donor OPN1LW-EGFP/NRL−/− cone photoreceptors differentiated into cone subtypes after long-term transplantation.•Photoreceptor sheet transplantation promoted greater graft integrity and cone survival than cell suspension transplantation.

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关键词

Degenerative retinal diseases,Age-related macular degeneration,Stem cell therapy,Cone photoreceptor,Cone transplantation,Optic coherence tomography

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