Sequential [3+2] Annulation Reaction Of Prop-2-Ynylsulfonium Salts And Hydrazonyl Chlorides: Synthesis Of Pyrazoles Containing Functional Motifs

A novel sequential [3+2] annulation reaction has been developed using prop-2-ynylsulfonium salts and hydrazonyl chlorides, affording a series of pyrazoles with functional motifs that can be post modified in the preparation of various drugs or drug candidates. Further transformation and gram-scale operations could also be achieved efficiently.