miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway

•miR-132-3p is upregulated in a cisplatin-induced AKI by small RNA sequencing.•miR-132-3p exacerbates the nephrotoxicity of cisplatin.•miR-132-3p directly binds and inhibits SIRT1 during inflammatory bursts.•Repression of SIRT1 by mir-132-3p rescinds the deacetylation of NF-κB.•Novel mechanisms of epigenetic regulation of inflammation in cisplatin-AKI.