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CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies

Loes F M van der Zanden,Iris A L M van Rooij,Josine S L T Quaedackers,Rien J M Nijman,Martijn Steffens,Liesbeth L L de Wall,Ernie M H F Bongers, Franz Schaefer,Marietta Kirchner,Rouven Behnisch,Aysun K Bayazit,Salim Caliskan,Lukasz Obrycki, Giovanni Montini,Ali Duzova,Matthias Wuttke,Rachel Jennings,Neil A Hanley,Natalie J Milmoe,Paul J D Winyard,Kirsten Y Renkema,Michiel F Schreuder,Nel Roeleveld,Wout F J Feitz

European Urology Open Science（2021）

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摘要
We found that variants of CDH12 increase the risk of kidney injury in patients with posterior urethral valves. This is the first time that this gene has been reported on in this context. Our study provides interesting new information about pathways involved in obstructive uropathies and important leads for further research.
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关键词
CDH12,Genome-wide association study,Obstructive uropathy,Posterior urethral valves
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