The spectrum of mitochondrial DNA (mtDNA) mutations in pediatric CNS tumors.

Kristiyana Kaneva,Katrina O'Halloran,Petr Triska,Xiyu Liu,Daria Merkurjev,Moiz Bootwalla,Alex Ryutov,Jennifer A Cotter,Dejerianne Ostrow,Jaclyn A Biegel,Xiaowu Gai

Neuro-oncology advances（2021）

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摘要

Our findings demonstrate varying contributions of mtDNA mutations in different subtypes of CNS tumors. Sequencing the mtDNA genome may ultimately be used to characterize CNS tumors at diagnosis and monitor disease progression.

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关键词

CBTN,CBTTC,CNS tumors,brain tumors,mitochondrial DNA,pediatric

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