Adjuvanticity Of Beta -Glucan For Vaccine Against Trichinella Spiralis
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY(2021)
Abstract
In the past 30 years, few researches focus on the efficacy of adjuvant against Trichinella spiralis infection. Identifying new, improved vaccine adjuvants for T. spiralis infection are required. beta-glucan are effective and safe as adjuvant for infectious diseases. In this paper, we first observed the adjuvanticity of beta-glucan as adjuvant for defensing helminth T. spiralis in vivo. We showed that IgG and IgE were elevated in the mice immunized with beta-glucan combined with recombinant T. spiralis serine protease inhibitor (rTs-Serpin), which is one of the vaccine candidates. Furthermore, in vitro, the combination of beta-glucan and rTs-Serpin enhanced the maturation of bone marrow dendritic cells (BMDCs) compared to rTs-Serpin alone. We showed that beta-glucan + rTs-Serpin -treated BMDCs secreted higher production of IL-12 and IL-10. Moreover, beta-glucan + rTs-Serpin -treated BMDCs not only promoted the population of CD4(+) IFN-gamma(+) T cells, but also enhanced the population of CD4(+) IL-4(+) T cells. These findings suggested that beta-glucan, as an adjuvant, have the capacity to protect against T. spiralis infection via activating both Th1 and Th2 immune response.
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Key words
Trichinella Spiralis, beta-glucan, adjuvant, dendritic cells, Th1/Th2 response
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