Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre

•Prophylactic cranial irradiation (PCI) was more commonly used in younger patients.•PCI utilization rates did not change throughout our 20-year institutional experience.•PCI was associated with improved OS and lower brain metastasis risk, independent of MRI follow-up or era of treatment.•For LS-SCLC patients with good thoracic response, PCI remains the standard-of-care.