Large scale regulatory T cells screening

Regulatory T cells (Tregs) expressing the transcription factor forkhead box protein 3 (Foxp3) play an essential role in establishing and maintaining immune tolerance. Indeed, Foxp3 deficiency, non-functional or hypomorphic mutations in Foxp3 gene, induce severe systemic autoimmunity and lymphoproliferative disorders observed in Scurfy mice and in immune dysregulation, polyendocrinopathy enteropathy, X-linked (IPEX) patients [1, 2].