Pharmacokinetic and metabolomics approach based on UHPLC-MS to evaluate therapeutic effect of lignans from S. Chinensis in alzheimer's disease

Yuan Zhou,Mengying Wei,Meiling Fan,Zhongying Liu,Aimin Wang,Yuanyuan Liu,Lihui Men,Zifeng Pi,Zhiqiang Liu,Fengrui Song

Journal of Chromatography B（2021）

引用 5|浏览6

暂无评分

摘要

•Different lignans metabolism was discovered between AD and normal rats.•Endogenous metabolite changes in AD rats were discussed after lignans treatment.•Correlation between lignans metabolism and endogenous metabolite changes was explored.•Quantitative detection method for 6 lignans without standards in plasma was established.

查看译文

关键词

Alzheimer’s disease,Schisandra chinensis (Turcz.) Baill,Lignans,UHPLC-MS,Pharmacokinetics,Metabolomics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要