Grafting of Connexin43 (Cx43) Overexpressing Cardiac Fibroblasts Protects from Postinfarct Arrhythmia

M Schiffer,E Carls, GD Dürr, H Treede, JM Delafuente,A Pfeifer

The Thoracic and Cardiovascular Surgeon49th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery（2020）

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摘要

Objectives: In the past, we could show a reduced incidence of postinfarct ventricular tachycardia (VT) following lentiviral transduction of resident fibroblasts (FB) with the gap junction protein Cx43. However transduction efficacy was very low and the underlying mechanisms of protection were therefore also not completely understood.

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cardiac fibroblasts protects,connexin43,cx43

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