Increased burden of rare variants in genes of the endosomal Toll-like receptor pathway in patients with systemic lupus erythematosus.

Tom N Lea-Henry,Aaron Chuah,Maurice Stanley,Vicki Athanasopoulos,Malcolm R Starkey,Daniel Christiadi,A Richard Kitching,Matthew C Cook,Thomas D Andrews,Carola G Vinuesa,Giles D Walters,Simon H Jiang

Lupus（2021）

引用 2|浏览14

暂无评分

摘要

Rare non-synonymous variants are enriched in patients with SLE in the eTLR pathway. This supports the hypothesis that SLE arises from several rare variants of relatively large effect rather than many common variants of small effect.

查看译文

关键词

Systemic lupus erythematosus,autoimmunity,endosomal Toll-like receptor pathway,genetics,next generation sequencing

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要