Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia.

Dimitrios Papaioannou,Hatice G Ozer,Deedra Nicolet,Amog P Urs, Tobias Herold,Krzysztof Mrózek,Aarif M N Batcha, Klaus H Metzeler,Ayse S Yilmaz,Stefano Volinia,Marius Bill,Jessica Kohlschmidt,Maciej Pietrzak,Christopher J Walker,Andrew J Carroll,Jan Braess,Bayard L Powell,Ann-Kathrin Eisfeld,Geoffrey L Uy,Eunice S Wang,Jonathan E Kolitz,Richard M Stone, Wolfgang Hiddemann, John C Byrd,Clara D Bloomfield,Ramiro Garzon

Haematologica（2021）

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摘要

Expression levels of long non-coding RNAs (lncRNAs) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNAs in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged.

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关键词

normal acute myeloid leukemia,genetic variants,cytogenetically,non-coding

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