COVID-19 diagnosis and testing in pediatric heart transplant recipients
The Journal of Heart and Lung Transplantation(2021)
摘要
Pediatric heart transplant recipients have been expected to be at higher risk of adverse events from developing COVID-19 infection. COVID-19 RNA PCR and antibody testing has been performed in our cohort of patients since March 15, 2020 and outcomes were reviewed. COVID-19 infection in our population of pediatric heart transplant recipients is common (21%), despite recommendations to avoid contact with others. Asymptomatic COVID-19 infection is common as well (55%). Despite the frequency of infection, COVID-19 is well tolerated in this population (5% admission from home; 0% mortality). A suppressed immune system does not significantly inhibit an antibody response in pediatric heart transplant recipients (>70% antibody seroconversion) and appears to persist, similar to those without transplantation (>90 days). Routine testing for COVID-19 via PCR and antibody testing enhances the ability to detect COVID-19 infection in asymptomatic patients and may help reduce unintended transmission to more susceptible individuals. J Heart Lung Transplant 2021;40:897-899 (c) 2021 International Society for Heart and Lung Transplantation. All rights reserved.
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关键词
KEYWORDS: COVID-19,SARS-CoV2,Pediatric Heart Transplant,Infection
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