Identification and characterization of quinoline alkaloids from the root bark of Dictamnus dasycarpus and their metabolites in rat plasma, urine and feces by UPLC/Qtrap-MS and UPLC/Q-TOF-MS

Journal of Pharmaceutical and Biomedical Analysis(2021)

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摘要
•The quinoline alkaloids profile of BXP and metabolites were characterized by LC–MS.•A stepwise manner based on DFIs, in-house database, ClogP and μ was proposed.•A total of 73 quinoline alkaloids were characterized in BXP extract.•57 prototypes and 41 metabolites were characterized in rat bio-samples.
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关键词
Dictamnus dasycarpus Turcz.,Quinolines,Metabolites,UPLC/Q-TOF-MS,UPLC/Qtrap-MS
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