A 1H NMR spectroscopic metabolomic study of the protective effects of irbesartan in a rat model of chronic mountain sickness

Yiliyaer Nijiati,Lianlian Shan,Tao Yang,Maiwulanijiang Yizibula,Ainiwaer Aikemu

Journal of Pharmaceutical and Biomedical Analysis（2021）

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摘要

•This is the first study of serum metabolites of CMS and treated with irbesartan.•Irbesartan may be a potential therapeutic agent for CMS.•Lung injury in rat was revealed by microstructural and ultrastructural changes.•Amino acid synthesis and energy metabolism play crucial roles in CMS.

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关键词

Irbesartan,Chronic Mountain Sickness,Lung tissue,Metabolomics

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