Heart rate characteristics monitoring and reduction in mortality or neurodevelopmental impairment in extremely low birthweight infants with sepsis

William E. King,Waldemar A. Carlo,T. Michael O'Shea,Robert L. Schelonka

Early Human Development（2021）

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摘要

We questioned whether a heart rate characteristics (HRC) sepsis risk score displayed to clinicians would modify 18-22 month neurodevelopmental outcomes for extremely low birthweight infants who develop sepsis. Infants allocated to HRC display with sepsis had a 12% absolute reduction in the composite outcome of death or neu-rodevelopmental impairment. Trial registration: NCT00307333

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关键词

Newborn infant,Infant,Infant health,Infant extremely low birth weight,Infant extremely premature,NICU,Heart rate characteristics HRC,Heart rate variability HRV,Randomized controlled trial RCT,Late onset sepsis LOS,Neurodevelopmental impairment NDI,Extremely low birth weight ELBW

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