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Varied thyroid disrupting effects of perfluorooctanoic acid (PFOA) and its novel alternatives hexafluoropropylene-oxide-dimer-acid (GenX) and ammonium 4,8-dioxa-3H-perfluorononanoate (ADONA) in vitro

Shouhua Zhang,Kuai Chen,Weiming Li,Yong Chai,Jian Zhu,Bingfeng Chu,Nuoya Li,Jinlong Yan,Shenglai Zhang,Yipeng Yang

Environment International（2021）

Cited 25|Views22
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Abstract
•GenX is more toxic than its predecessor PFOA in thyroid cells.•ADONA has minimal cytotoxicity on thyroid cells.•PFOA, GenX and ADONA all affect gene expression in thyroid cells.•Short-chain PFASs are not necessarily safer than long-chain PFAS.
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Key words
Thyroid disruption,Cell viability,Perfluorooctanoic acid,Hexafluoropropylene-oxide-dimer-acid,Ammonium 4,8-dioxa-3H-perfluorononanoate
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