The effect of CYP2D6 and CYP2C9 gene polymorphisms on the efficacy and safety of the combination of tramadol and ketorolac used for postoperative pain management in patients after video laparoscopic cholecystectomy.

Andranik Alexandrovich Muradian,Dmitry Alekseevich Sychev,Dmitry Alekseevich Blagovestnov,Zhannet Alimovna Sozaeva,Kristina Anatolyevna Akmalova, Michael Sergeevich Zastrozhin, Leyla Nabievna Kerimova, Vadim Teymurazovich Koroshvili, Irina Alexandrovna Epifanova

Drug metabolism and personalized therapy（2021）

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Abstract

and can predict analgesic effectiveness of tramadol and ketorolac. can predict the risk of gastrointestinal bleeding, including those hidden to ketorolac.

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Key words

CYP2C9,CYP2D6,ketorolac,non-steroidal anti-inflammatory drugs (NSAIDs),pharmacogenetics,tramadol

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