Ageing mechanisms that contribute to tissue remodeling in lung disease

Michael Schuliga,Jane Read,Darryl A. Knight

Ageing Research Reviews（2021）

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摘要

•Ageing leads to declines in lung health, function and resilience.•Ageing pre-disposes the lung for disrepair, increasing disease susceptibility.•Pathological remodeling, rather than wound repair is likely to follow injury.•IPF, COPD, ARDS and severe phenotypes of asthma are age-related lung diseases.•Ageing mechanisms are potential therapeutic targets for these diseases.

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关键词

Acute respiratory distress syndrome (ARDS),Chronic obstructive pulmonary disease (COPD),Damage associated molecular pattern (DAMP),Idiopathic pulmonary fibrosis (IPF),Immunosenescence,Mitochondrial dysfunction

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