Vesiculobullous skin reactions induced by COVID-19 mRNA vaccine: report of four cases and review of the literature

COVID-19 vaccines are proving to be the most important medical tool to prevent and control the current pandemic (1). The skin is reported as the target organ where post-vaccination adverse reactions are frequently detected (2). The potential for vaccines to act as triggers of autoimmune reactions is a well-known adverse effect. COVID-19 mRNA vaccines might differently stimulate myeloid or plasmacytoid dendritic cells, generating an imbalance in the downstream cytokine pathways that play a crucial role in autoimmunity and autoinflammation (3).