Pillar[5]Arene-Based Supramolecular Photosensitizer For Enhanced Hypoxic-Tumor Therapeutic Effectiveness

A galactose-targeting supramolecular photosensitizer system DOX@GP5 superset of NBSPD was constructed based on a host-guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.