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G-Quadruplex Dna Inhibits Unwinding Activity But Promotes Liquid-Liquid Phase Separation By The Dead-Box Helicase Ded1p

Jun Gao,Zhaofeng Gao,Andrea A Putnam,Alicia K Byrd,Sarah L Venus,John C Marecki,Andrea D Edwards, Haley M Lowe,Eckhard Jankowsky,Kevin D Raney

CHEMICAL COMMUNICATIONS（2021）

Cited 9|Views12
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Abstract
G-quadruplex DNA interacts with the N-terminal intrinsically disordered domain of the DEAD-box helicase Ded1p, diminishing RNA unwinding activity but enhancing liquid-liquid phase separation of Ded1p in vitro and in cells. The data highlight multifaceted effects of quadruplex DNA on an enzyme with intrinsically disordered domains.
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Key words
dna,liquid–liquid phase separation,g-quadruplex,dead-box
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