Braf Mutation Induces Rapid Neoplastic Transformation In The Aged And Aberrantly Methylated Intestinal Epithelium
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY(2021)
摘要
SSLs arising in the aged intestine are at a significantly higher risk of spontaneous neoplastic progression. These findings provide support for a new conceptual model for serrated colorectal carcinogenesis, whereby risk of induced neoplastic transformation is dependent on age and may be related to age-associated molecular alterations that accumulate in the ageing intestine, including DNA methylation. This may have implications for surveillance and chemopreventive strategies targeting the epigenome.
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关键词
adenocarcinoma,ageing,colonic polyps,colorectal neoplasia,oncogenes
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