Does neocytolysis exist after descent from high altitude?

Neocytolysis is a transient destruction of hypoxia-generated young red cells upon rapid change from hypoxia to normoxia, or upon return from space flight. The term neocytolysis was coined by Alfrey and Rice and colleagues . In a recent report, published in Acta Physiol, Klein and coworker questioned the existence of neocytolysis . This directly contradicts the data from Alfrey and Rice and their study of Andeans descending from Cerro de Pasco at 4380 to Lima at sea level.