SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

Oladapo E Olaniru,Jordan Cheng,Julia Ast,Anastasia Arvaniti,Patricio Atanes,Huang Gc, Aileen J F King,Peter M Jones,Johannes Broichhagen,David J Hodson,Shanta J Persaud

Molecular Metabolism（2021）

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摘要

•GPR56 predominantly underwent constitutive internalisation in β-cells in the absence of exogenous agonist.•The GPR56 agonists, collagen III and P7, showed differential effects on GPR56 trafficking and islet functions.•Constitutive and agonist-dependent GPR56 activation is coupled to protection of β-cells against apoptosis.

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关键词

GPR56,SNAP-tag,Trafficking,Islets,Apoptosis,CRISPR-Cas9

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