Eu3+-doped layered gadolinium hydroxides as drug carriers and their bactericidal behavior
Materials Science and Engineering: C(2021)
摘要
Layered rare earth hydroxides (LRHs) due to outstanding photoluminescence (PL) properties and anion exchangeability are extensively reported in multiple fields. In this work, the drug-loaded and bactericidal behaviors of Eu3+-doped layered gadolinium hydroxides (LGdHs:Eu) as optical carriers were explored through intercalation and release of cephalexin (CE). In the intercalation state, the PL intensity of CEˉ-LGdHs:Eu obviously decreased because of the quenching effect of CEˉ. And the PL intensity of LGdHs:Eu was restored with the release of CEˉ ions in phosphate buffer solutions (PBS). A significant functional relationship between the drug releasing amount and PL intensity ratio was found, providing a novel optical method to specify the drug dosage. And CEˉ-LGdHs:Eu showed the excellent bactericidal properties in both in vivo and in vitro experiments.
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关键词
Layered rare earth hydroxides,Drug carrier,Drug release,Bactericidal effect
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