Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

J Gebert,O Gelincik, M Oezcan-Wahlbrink, J D Marshall, A Hernandez-Sanchez, K Urban,M Long,E Cortes,E Tosti, E M Katzenmaier, Y Song, A Elsaadi,N Deng, E Vilar, V Fuchs, N Nelius, Yuan,A Ahadova,S Sei, R H Shoemaker,A Umar,L Wei,S Liu,P Bork,W Edelmann,M von Knebel Doeberitz,S M Lipkin,M Kloor

Gastroenterology（2021）

引用 51|浏览7

暂无评分

摘要

Vaccination of Lynch syndrome mice with shared immunogenic frameshift peptide neoantigens derived from recurrent frameshift mutations reduced intestinal tumor formation and prolonged survival, even more efficiently upon parallel nonsteroidal anti-inflammatory drug treatment.

查看译文

关键词

Colorectal Cancer,Frameshift Neoantigens,Lynch Syndrome,Mouse Model,Preventive Cancer Vaccine

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要