Transcriptome and chromatin landscape changes associated with trastuzumab resistance in HER2+ breast cancer cells

Rabi Murad,Arabo Avanes,Xinyi Ma,Shuhui Geng,Ali Mortazavi,Jamil Momand

Gene（2021）

引用 12|浏览7

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摘要

•Mapped chromatin accessible areas in PPP1R1B associated with trastuzumab resistance.•FoxJ3 and Pou5A1/Sox2 transcription factor motifs are protected in PPP1R1B.•Autophagy and mitochondria organization genes are upregulated in resistant cells.•Ribosome assembly genes are downregulated in resistant cells.•The ETV5 transcription factor is upregulated in resistant cells.

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AKT1,ATAC-seq,FDR,RSEM,t-Darpp,TPM

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