Seronegative necrotizing autoimmune myopathy with favorable response to intravenous immunoglobulin.
Proceedings (Baylor University. Medical Center)(2021)
摘要
We describe a 68-year-old man who presented with progressive weakness in proximal muscles of all four limbs and was found to have autoantibody-negative necrotizing autoimmune myopathy (NAM). His myopathy was refractory to corticosteroids and methotrexate, but subsequently demonstrated successful response to intravenous immunoglobulin (IVIG). The patient also received rituximab, but the timing of his recovery favored IVIG as the more important factor in terms of efficacy. Treatment guidelines for seronegative necrotizing myopathies are lacking. This case suggests a potential efficacious treatment option for the seronegative subset of NAM.
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关键词
HMGCR,SRP,immune-mediated necrotizing myopathy,myositis,necrotizing autoimmune myopathy
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