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Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway

Jia Liu,Guorong Yan,Qi Chen,Qingyu Zeng,Xiuli Wang

The International Journal of Biochemistry & Cell Biology（2021）

Cited 10|Views9
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Abstract
•M-PDT inhibits cSCC cell proliferation by activating p-JNK, p-p38 and inhibiting p-Erk1/2.•M-PDT inhibits cSCC cell proliferation by inhibiting PP5 and demethylation/phosphorylation of PP2A.•M-PDT inhibits cSCC cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway.
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Key words
JNK,MAPK,MKP1,PP2A,PP5,ROS,ALA-PDT
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