Fibroscan (R) Probe Selection For Lean Adults
JGH OPEN(2021)
Abstract
Background and Aim Fibroscan (R) is used to assess fibrosis and steatosis of the liver noninvasively. The company suggests to use the S+-probe in people <18 years with a thoracic circumference (TC) between 45 and 75 cm and the M+-probe in children with a TC >75 cm and adults with a skin-liver capsule distance <2.5 cm. For lean adults with a TC <= 75 cm, no comparative studies have been performed. Furthermore, it is unclear whether lean adults need to be fasted before assessment.Methods We compared liver stiffness (LS) using Fibroscan (R) S+- and M+-probes and controlled attenuation parameter (CAP; only available for M+-probe) in healthy volunteers with a TC <= 75 cm compared with those with a TC >75 cm in fasting state and after intake of a standardized light meal (300 kcal).Results We examined 50 volunteers (26 female, 24 +/- 3 years). Twenty-two participants were in the TC <= 75 cm group and 28 in TC >75 cm group. LS values with the S+-probe were 15% higher than with the M+-probe in both groups (median difference 0.6 kPa, P < 0.001). Both probes showed good agreement with minimal bias (Spearman correlation r = 0.754, P < 0.001; Interclass Correlation Coefficient 0.843, P < 0.001; Bland-Altman bias 0.6 +/- 0.9 kPa, linear regression r(2) = 0.557, P < 0.001). Intake of a light meal had no relevant influence on LS (S+- and M+-probes) or CAP measurements (M+-probe) in both groups.Conclusion Lean adults with a TC below 75 cm can be assessed with either the S+-probe or the M+-probe and may take a light meal before assessment.
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Key words
agreement, bias, examination, liver stiffness, meal, preparation, steatosis, thoracic circumference, transient elastography
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