Synthesis, Structure, and Biological Activity of Palladium(II) Complexes with Some 1- and 2-Substituted Tetrazole Ligands

A series of palladium(II) complexes with 1 H - and 2 H -tetrazole ligands (2-isopropyl-5-R-2 H -tetrazoles and 1 H -tetrazol-1-ylcarboxylic acids) was synthesized. Structure of the obtained compounds was confirmed by 1 H and 13 C NMR spectroscopy, high-resolution mass spectrometry, and single crystal X-ray diffraction analysis. According to the spectrophotometry data, the complexes are weakly bound to DNA. The cytotoxic activity of the obtained palladium complexes was studied in vitro .