In vitro and in cellulo anti-diabetic activity of AuI- and AuIII-isothiourea complexes

Sharmeen Fayyaz,Muniza Shaikh,Danila Gasperini,Steven P. Nolan,Andrew D. Smith,M. Iqbal Choudhary

Inorganic Chemistry Communications（2021）

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摘要

•isothiourea gold complexes were evaluated as novel DPP-IV inhibitors.•In vitro enzyme inhibition assay was performed.•Moderate DPP-IV inhibitory activity observed in in cellulo model.•Mechanistic studies were performed to identify mechanism of inhibition.

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关键词

Gold complexes,Dipeptidyl peptdase-IV,Diabetes type 2,Caco-2 cells,Isothiourea,Bioinorganic chemistry

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