API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in Cgmp Manufacturing

Martin D. Johnson,Christopher L. Burcham,Scott A. May,Joel R. Calvin,Jennifer McClary Groh,Steven S. Myers,Luke P. Webster,Jeffrey C. Roberts,Venkata Ramana Reddy,Carla Luciani, Aoife P. Corrigan,Richard D. Spencer,Robert Moylan, Raymond Boyse,John D. Murphy,James R. Stout

Organic Process Research & Development（2021）

引用 26|浏览28

关键词

continuous crystallization,kinetic impurity rejection,MSMPR,cooling and antisolvent,cGMP manufacturing,scale-up,startup and shutdown,continuous distillation,solids fouling,encrustation,supersaturation,control strategy,population balance,kinetics modeling,particle size distribution,microscopy,form control,residence time distribution

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要