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Endemic SARS-CoV-2 Polymorphisms Can Cause a Higher Diagnostic Target Failure Rate than Estimated by Aggregate Global Sequencing Data

Daniel D Rhoads,David Plunkett,Joy Nakitandwe, Andrew Dempsey,Zheng Jin Tu,Gary W Procop,David Bosler,Brian P Rubin,Michael J Loeffelholz,Jay E Brock

JOURNAL OF CLINICAL MICROBIOLOGY（2021）

Cited 14|Views22
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate during the ongoing COVID-19 pandemic, and some of the nucleotide polymorphisms may result in diagnostic detection failures.….
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Key words
nucleocapsid gene, PCR, SARS-CoV-2, mutation, variant
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