Pd‐Catalyzed Amidation of Silyl Enol Ethers with CO and Azides via an Isocyanate Intermediate

An efficient Pd-catalyzed amidation of silyl enol ethers to produce beta-ketoamides has been developed using carbon monoxide and sulfonyl azides. The tandem reaction provides a simple and straightforward approach for the synthesis of beta-ketoamides under mild conditions without any additive. The mechanistic studies indicate that the reaction undergoes via an in situ generated isocyanate intermediate.