Pf4 Immunoassays In Vaccine-Induced Thrombotic Thrombocytopenia

Laboratory Method to Detect VITTThe rare vaccine-induced immune thrombotic thrombocytopenia that may follow adenovirus-based Covid-19 vaccination resembles heparin-induced thrombocytopenia, but rapid assays for anti-PF4 antibodies used to diagnose HIT may be negative in patients with VITT. The PF4-serotonin release assay appears to detect the IgG antibodies to PF4-PVS that mediate this condition.