microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson’s disease
Neuroscience Letters（2021）
Abstract
•EVs-miR-106b from MSC alleviates neuronal injury in PD mice.•EVs-miR-106b from MSC promotes autophagy and inhibits neuronal apoptosis in PD.•miR-106b targets and negatively regulates CDKN2B expression.•CDKN2B reverses the promoting effects of EVs-miR-106b on neuronal autophagy.•EVs-miR-106b inhibits CDKN2B expression and alleviates neurological damage in PD.
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Key words
Parkinson’s disease,Mesenchymal stem cell-derived extracellular vesicles,microRNA-106b,CDKN2B,Autophagy,Neuron
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